Nottingham Prognostic Index

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The Nottingham prognostic index (NPI) is used to determine prognosis following surgery for breast cancer. Its value is calculated using three pathological criteria: the size of the lesion; the number of involved lymph nodes; and the grade of the tumour.

Video Nottingham Prognostic Index

Calculation

The index is calculated using the formula:

NPI = [0.2 x S] + N + G

Where:

• S is the size of the index lesion in centimetres
• N is the node status: 0 nodes = 1, 1-3 nodes = 2, >3 nodes = 3
• G is the grade of tumour: Grade I =1, Grade II =2, Grade III =3

Maps Nottingham Prognostic Index

Interpretation

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References

• Haybittle JL, Blamey RW, Elston CW, Johnson J, Doyle PJ, Campbell FC, Nicholson RI, Griffiths K. A prognostic index in primary breast cancer. British journal of cancer. 1982 Mar; 45(3):361-6.
• Todd JH, Dowle C, Williams MR, Elston CW, Ellis IO, Hinton CP, et al. Confirmation of a prognostic index in primary breast cancer. British journal of cancer. 1987;56:489-92
• Galea MH, Blamey RW, Elston CE, Ellis IO. The Nottingham Prognostic Index in primary breast cancer. Breast Cancer Research & Treatment 1992;22(3):207-19
• Garner J, Goodfellow P The Nottingham Prognostic Index Questions for the MRCS vivas 2004 First Edition Page 231

src: cancerres.aacrjournals.org

External links

• Online calculator based on Todd et al, 1987 study
• The Nottingham Prognostic Index Biomedical Informatics Research Group
• Nottingham prognostic index Ganfyd

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